Analysis of extraskeletal function of vitamin d and cardiovascular risk factors in patients with psoriasis
- Autores: Jacinto Orgaz Molina
- Directores de la Tesis: Salvador Arias Santiago (dir. tes.), Miguel Ángel Arrabal Polo (codir. tes.), Agustín Buendia Eisman (codir. tes.)
- Lectura: En la Universidad de Granada ( España ) en 2013
- Idioma: español
- Tribunal Calificador de la Tesis: Salvio Serrano Ortega (presid.), Francisco Javier Gómez Jiménez (secret.), Americo Figueiredo (voc.), Mercedes Zubiaur Marcos (voc.), Ricardo Juan Bosch García (voc.)
- Materias:
- Enlaces
- Tesis en acceso abierto en: DIGIBUG
- Resumen
In recent years there has been described an increased prevalence of cardiovascular disease associated with increased mortality in patients with psoriasis. Psoriasis is a chronic inflammatory disease pathogenically characterized by an unbalanced immune expression in favor of a predominant Th1 response. Moreover, cardiovascular disease today is defined as a chronic inflammatory disease with pathogenic phenomena similar to those observed in plaque psoriasis.
Moreover, a lower level of vitamin D has been described in connection with certain chronic inflammatory diseases, such as multiple sclerosis, lupus or rheumatoid arthritis. Also, it has been noted an inverse relationship between serum vitamin D and the prevalence and mortality associated with cardiovascular diseases.
On this basis, we decided to conduct a study to compare cardiovascular risk factors (through assessment of the presence of MS and carotid atheroma) in psoriatic patients compared with a control group and evaluate this cardiovascular risk with clinical parameters of psoriasis and inflammatory parameters.
Moreover, in the literature there is a lack of studies on vitamin D in patients with psoriasis and their relationship with cardiovascular risk. Therefore, we evaluated the serum concentration of vitamin D in patients with psoriasis compared with a control group and its relationship with SM and carotid atheromatosis.
