Design and development of novel cyclosporine A lipid nanoparticle formulations appropriate for oral delivery

• Autores: Melissa Guada .
• Directores de la Tesis: María José Blanco Prieto (dir. tes.), María del Carmen Dios Vieitez (dir. tes.)
• Lectura: En la Universidad de Navarra ( España ) en 2016
• Idioma: inglés
• Número de páginas: 131
• Tribunal Calificador de la Tesis: Ángel Concheiro Nine (presid.), Azucena Aldaz Pastor (secret.), Julen Oyarzabal Santamarina (voc.), Antonio José Leitâo das Neves Almeida (voc.), Ana Isabel Torres Suárez (voc.)
• Materias:
  • Ciencias médicas
    • Farmacodinámica
      • Absorción de medicamentos
    • Farmacología
      • Evaluación de medicamentos
      • Preparación de medicamentos
• Enlaces
  • Tesis en acceso abierto en: Dadun
• Resumen

  • Cyclosporine A (CsA) is a well-known immunosuppressive agent that gained considerable importance in transplant medicine in the late 1970s due to its selective and reversible inhibition of T-lymphocytes. While CsA has been widely used to prevent graft rejection in patients undergoing organ transplant it was also used to treat several systemic and local autoimmune disorders. Currently, the neuro- and cardio-protective effects of CsA (CiCloMulsion®; NeuroSTAT®) are being tested in phase II and III trials respectively and NeuroSTAT® received orphan drug status from US FDA and Europe in 2010. The reformulation strategies focused on developing Cremophor® EL free formulations and address variable bioavailability and toxicity issues of CsA. This review is an attempt to highlight the progress made so far and the room available for further improvements to realize the maximum benefits of CsA.