African Swine Fever Virus-mediated regulation of RNA metabolism: g5Rp, a putative viral decapping enzyme

• Autores: Ana Quintas Gorozarri
• Directores de la Tesis: Yolanda Revilla Novella (dir. tes.)
• Lectura: En la Universidad Autónoma de Madrid ( España ) en 2015
• Idioma: inglés
• Tribunal Calificador de la Tesis: José María Almendral del Río (presid.), Ricardo Madrid González (secret.), Javier Mª Rodriguez Martinez (voc.), Encarnación Martínez Salas (voc.), Mariano Esteban Rodríguez (voc.)
• Calificación: Sobresaliente Cum Laude
• Materias:
  • Ciencias de la vida
    • Biología molecular
• Enlaces
  • Tesis en acceso abierto en: Biblos-e Archivo
• Resumen

  • African Swine Fever Virus (ASFV) is a large, cytoplasmic, double-stranded DNA virus that infects different species of swine, including domestic pigs and wild suids, and causing an aconomically important disease against which no vaccine exists so far.

    The vast majority of animal cytolytic viruses interfere with celular gene expression after infection of host cells. Cellular protein synthesis in particular is usually abrogated at times when late viral proteins are being synthesized. Similarly to VV infection, during ASFV infection P-elF2alfa levels decrease at early times post infection, and remain undetectable throughout the infection. (extracto sacado del informe de la doctora Dª. Yolanda Revilla Novella)