Monosodium glutamate disrupts methionine metabolism to induce transgenerational infection susceptibility in C. elegans

• Autores: Shiye Lin
• Directores de la Tesis: Juan Carlos Mejuto Fernández (dir. tes.), Cao Hui (dir. tes.)
• Lectura: En la Universidade de Vigo ( España ) en 2026
• Idioma: inglés
• Programa de doctorado: Programa de Doctorado en Ecosistemas Terrestres, Uso Sostenible e Implicaciones Ambientales por la Universidad de Vigo
• Materias:
  • Química
    • Bioquímica
      • Otras especialidades de bioquímica
• Enlaces
  • Tesis en acceso abierto en: Investigo
• Resumen

  • Monosodium glutamate (MSG) is one of several forms of glutamic acid found in foods, in large part because glutamic acid (an amino acid) is pervasive in nature. Nowadays, it has been widely sed in the food industry as a flavor enhancer with an umami taste that intensifies the meaty, savory flavor of food, as naturally occurring glutamate does in foods such as stews and meat soups. However, multiple studies have indicated that indicates that MSG exerts adverse effects on humans, including metabolic syndrome, neurotoxicity, renal toxicity, cardiovascular disease, infertility and fetal underdevelopment, cancer, immune malfunction and so on. Particularly, the excess intake of MSG produces reactive oxygen species to cause oxidative stress-induced splenic anomalies and suppress the inflammatory response. However, it is still not clear that if MSG-induced immunosuppression effects can be inherited to the offspring. Caenorhabditis elegans (C. elgans) has been confirmed to be powerful model in the innate immunity and transgenerational effects. Polyphenols enriched in the diet have been shown to exert diverse immunomodulatory effects in various in vitro and in vivo models, primarily through epigenetic mechanisms such as DNA and RNA methylation, regulation by non-coding RNAs, chromatin remodeling, and histone modifications. Notably, polyphenols have been reported to alleviate monosodium glutamate (MSG)-induced immunosuppression. In the present study, the transgenerational effects of MSG-induced immunosuppression are systematically investigated using C. elegans as a model organism. Moreover, the potential of polyphenols to ameliorate transgenerational immunosuppression through epigenetic modifications is also evaluated.