The Povarov reaction as a strategy for constructing structurally complex heterocycles and their biological and computational evaluation as Topoisomerase 1 inhibitors

• Autores: Angela Trejo Nogales
• Directores de la Tesis: Concepcion Alonso Pérez (dir. tes.), Carme Masdeu Margalef (codir. tes.)
• Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2025
• Idioma: inglés
• Programa de doctorado: Programa de Doctorado en Química Sintética e Industrial por la Universidad del País Vasco/Euskal Herriko Unibertsitatea y la Universidad Pública de Navarra
• Menciones:
  • Internacional
• Calificación: Sobresaliente Cum Laude
• Materias:
  • Química
• Enlaces
  • Tesis en acceso abierto en: ADDI
• Resumen

  • The present Doctoral Thesis investigates the use of the Povarov reaction as a synthetic tool for the preparation of nitrogen-containing heterocyclic compounds, including phenanthroline derivatives and analogues of the drug sulfadoxine. Different modalities of the reaction are explored, including one-pot and multicomponent approaches, while the intramolecular variant is specifically applied to access heterocycles of higher structural complexity. The biological activity of the synthesized derivatives is evaluated, focusing on both their antiproliferative and antimicrobial potential, with particular emphasis on their interaction with topoisomerase I as a molecular target. These experimental studies are further supported by computational analyses aimed at generating a well-founded hypothesis on the compounds’ binding mode.