Characterization of a prodromal mouse model of Parkinson’s Disease overexpressing alpha-synuclein in the Locus Coeruleus
- Autores: Jone Razquin Lizarraga
- Directores de la Tesis: Cristina Miguélez Palomo (dir. tes.), Naiara Ortuzar Markes (codir. tes.)
- Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2025
- Idioma: inglés
- Títulos paralelos:
- Locus Coeruleus-ean alfa-sinukleinaren gainadierazpenean oinarritutako Parkinson gaixotasunaren sagu eredu prodromal baten karakterizazioa
- Programa de doctorado: Programa de Doctorado en Farmacología por la Universidad del País Vasco/Euskal Herriko Unibertsitatea
- Menciones:
- Internacional
- Calificación: Sobresaliente Cum Laude
- Materias:
- Enlaces
- Tesis en acceso abierto en: ADDI
- Resumen
Parkinson's Disease is a neurodegenerative disorder characterized by the appearance of Lewy bodies in various brain regions, disruption of neurotransmitter systems, and the presence of motor and non-motor symptoms. Despite significant advancements, the pathological mechanisms and progression of neuronal degeneration in PD remain poorly understood. The locus coeruleus, one of the earliest brain regions affected in the disease, exhibits Lewy bodies and PD-like pathology during the presymptomatic phase and has been associated with non-motor symptoms of the disorder.
In this work we have characterized a mice model overexpressing a-synuclein, the principal component of Lewy bodies, selectively in the locus coeruleus. The model was analyzed histologically, behaviourally and functionally. This dissertation highlights the importance of noradrenergic dysfunction in the pathophysiology of Parkinson Disease.
