Translating Photoredox Catalysis to Biological Environments
- Autores: Xulián Fernández González
- Directores de la Tesis: María Tomás Gamasa (dir. tes.), José Luis Mascareñas Cid (dir. tes.)
- Lectura: En la Universidade de Santiago de Compostela ( España ) en 2026
- Idioma: inglés
- Programa de doctorado: Programa de Doctorado en Ciencia y Tecnología Química por la Universidad de Santiago de Compostela y la Universidad de Vigo
- Enlaces
- Tesis en acceso abierto en: MINERVA
- Resumen
This thesis explores the feasibility of performing photocatalytic radical processes in biological media, employing homogeneous and heterogeneous catalysis under a bioorthogonal context. First, we demostrated for the first time the photoredox activation of diazonium salts in biological and cellular environments, enabling radical transformations in cellulo. Subsequently, triazenes were introduce as stable precursors of diazonium salts, allowing the controlled generation of diazonium ion under aqueous and biocompatible conditions. As alternative radical precursors, we have explores the use of oximes for the generation of radical species under aqueoues conditions and within living cells. Finally, metal organic framewroks(MOF) were employeed as photocatalytic nanoreactors in aqueoues and biologically relevant environments.
