IC-Tagging system: from protein tracking to therapeutic applications

• Autores: Paula Sánchez Gascón
• Directores de la Tesis: Natalia Barreiro Piñeiro (dir. tes.), José Manuel Martínez Costas (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2025
• Idioma: inglés
• Tribunal Calificador de la Tesis: Francisco Javier Ortego Alonso (presid.), Marco Eugenio Vázquez Sentís (secret.), Nerea Irigoyen Vergara (voc.)
• Programa de doctorado: Programa de Doctorado en Medicina Molecular por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias de la vida
    • Inmunología
      • Vacunas
    • Biología molecular
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • The IC-Tagging system is a molecular tagging technology credited with multiple applications. In this thesis we explore three different potential applications in protein tracking and int the therapeutic field.

    First, an innovative sensor was designed to monitor protein retro-translocation in vitro, providing key insights into this cellular process. Additionally, the therapeutic potential of the system was investigated through the development of a vaccine candidate for immunotherapy in the B16-OVA pseudo-metastasis model, that triggers an effective immune response. Finally, a prototype vaccine for enveloped viruses was designed, opening new possibilities in the field of viral vaccination.

    These advancements highlight the versatility of IC-Tagging in both basic research and biomedical applications.