Evolución de virus respiratorios sincitiales humanos que tienen una duplicación de 60 nucleótidos en el gen de la proteína G

• Autores: Maria Alfonsina Trento
• Directores de la Tesis: José Antonio Melero Fondevila (dir. tes.)
• Lectura: En la Universidad Autónoma de Madrid ( España ) en 2009
• Idioma: español
• Tribunal Calificador de la Tesis: Esteban Domingo Solans (presid.), José María Almendral del Río (secret.), Amelia Nieto Martín (voc.), Juan Ortín Montón (voc.), Enrique Villar Ledesma (voc.)
• Programa de doctorado: Biología Molecular
• Materias:
  • Ciencias de la vida
    • Biología molecular
• Enlaces
  • Tesis en acceso abierto en: Biblos-e Archivo
• Resumen

  • Human respiratory syncytial virus (HRSV) belongs to the family Paramyxoviridae.

    It is the main cause of severe lower respiratory tract infections in very young children and is also a common cause of respiratory infections in elderly and immunocompromised individuals. Currently, no effective vaccine exists against this virus. Studies of HRSV evolution by sequence analysis have focused mainly on the G protein gene for two reasons: i) the G protein displays the highest antigenic and genetic variability among HRSV gene products and ii) the G protein is one of the targets for neutralizing and protective antibodies.