Biomaterials based on LMWG-polymer multicomponent supramolecular hydrogels

• Autores: Bárbara Giménez Hernández
• Directores de la Tesis: Beatriu Escuder Gil (dir. tes.)
• Lectura: En la Universitat Jaume I ( España ) en 2025
• Idioma: inglés
• Número de páginas: 200
• Tribunal Calificador de la Tesis: María J. Vicent Docon (presid.), Ana María García Fernández (secret.), Mathieu Surin (voc.)
• Programa de doctorado: Programa de Doctorado en Ciencias por la Universidad Jaume I de Castellón
• Materias:
  • Ciencias tecnológicas
    • Tecnología de materiales
      • Propiedades de materiales
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • Supramolecular hydrogels are formed through the self-assembly of low-molecular-weight gelators (LMWGs) in water, creating three-dimensional fiber networks via non-covalent interactions. The primary drawback of supramolecular hydrogels is their generally low mechanical strength. Therefore, the fabrication of hybrid LMWG-biopolymer materials is a useful strategy to enhance the final properties of the material. In this context, the synthesis of novel supramolecular hybrid hydrogels combining LMWGs with biopolymers for use as multicomponent biomaterials is notably relevant. On one hand, LMWG-polymer conjugates are prepared by synthesizing two low-molecular-weight peptide fragments that are covalently linked to the polymer, L-polyglutamic acid (PGA). On the other hand, multicomponent supramolecular hydrogels are developed. These hydrogels are formulated using biocompatible polymers such as hyaluronic acid (HA), L-polyglutamic acid (PGA), or different gelatins, which are combined with a supramolecular gelator based on dipeptides.