Atropine-loaded contact lenses for myopia control: design and preclinical evaluation
- Autores: Inés Ángela García del Valle
- Directores de la Tesis: Carmen Álvarez Lorenzo (dir. tes.)
- Lectura: En la Universidade de Santiago de Compostela ( España ) en 2024
- Idioma: inglés
- Tribunal Calificador de la Tesis: Carlos Alberto García González (presid.), Marta Vicario de la Torre (secret.), Herminio Sousa (voc.)
- Programa de doctorado: Programa de Doctorado en Investigación y Desarrollo de Medicamentos por la Universidad de Santiago de Compostela
- Materias:
- Enlaces
- Tesis en acceso abierto en: MINERVA
- Resumen
Myopia is a global public health priority due to its increasing prevalence in children. This PhD Thesis was aimed to the design of contact lenses (CLs) that load and elute therapeutically relevant amounts of atropine for a dual physical and pharmacological intervention. Functional monomers of different nature were combined at specific ratios to modulate the amounts of drug loaded and to achieve sustained release.
The preclinical evaluation of atropine-loaded CLs included in vivo models to assess ocular tissue distribution and penetration to the posterior segment. Parameters of the synthesized hydrogels related to CLs comfort and wearability were characterized, including oxygen permeability. The findings support the possibility of obtaining dual prospective interventions for the control of myopia progression.
