New supramolecular concepts for the development of functional systems in cells and protocells

• Autores: Alicia Rioboo
• Directores de la Tesis: Javier Montenegro García (dir. tes.), Juan Granja Guillan (codir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2024
• Idioma: español
• Tribunal Calificador de la Tesis: Andreas Walther (presid.), María Dolores Pérez Meiras (secret.), Claudia Contini (voc.)
• Programa de doctorado: Programa de Doctorado en Ciencia y Tecnología Química por la Universidad de Santiago de Compostela y la Universidad de Vigo
• Materias:
  • Química
    • Bioquímica
      • Péptidos
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• Resumen

  • In this manuscript, we have approached the development of new functional supramolecular systems from a chemical perspective and with the objective to modify or replicate cellular functions. The main driving force of the three chapters of this work share a dynamic character of stimuli-responsive systems, which is crucial for their specific functional behaviour. The novel functional systems development focused on a protofilament cytoskeleton-mimetic system, a new ratiometric fluorescent SNARF probe with pH range sensitivity optimized and a pH sensitive antitumoral analogue of a natural venom.