Development of novel biomimetic electroactive environments with bioactive molecules for musculoskeletal regeneration

• Autores: José Luis Aparicio Collado
• Directores de la Tesis: Roser Sabater Serra (dir. tes.), José Molina-Mateo (dir. tes.)
• Lectura: En la Universitat Politècnica de València ( España ) en 2023
• Idioma: español
• Tribunal Calificador de la Tesis: Ana Vallés Lluch (presid.), Cristina González García (secret.), Aleixandre Rodrigo Navarro (voc.)
• Programa de doctorado: Programa de Doctorado en Biotecnología por la Universitat Politècnica de València
• Materias:
  • Química
    • Química analítica
      • Análisis de polímeros
    • Química macromolecular
      • Polímeros compuestos
  • Ciencias tecnológicas
    • Tecnología de materiales
• Enlaces
  • Tesis en acceso abierto en: RiuNet
• Resumen

  • The musculoskeletal system can self-regenerate in a limited way. Major tissue losses cannot be regenerated, resulting in necrosis and functional impairment. Traditional treatments based on implants or transplants have not proven to be completely successful, with multiple side effects such as immunogenicity or rejections. Therefore, it is very important to develop new alternatives to treat muscle degeneration. Tissue engineering combines biomaterials, cells and bioactive agents to develop biological and biocompatible constructs where cells find an in vivo likely environment to grow, proliferate and differentiate into muscle tissue and restore its functionality.

    Conductive biomaterials are of particular interest in electrosensitive tissues such as the musculoskeletal system. Conductive polymers (polypyrrole, polyaniline, etc.), carbon materials (graphene, reduced graphene oxide, etc.) and metal nanomaterials have proved to enhance cell differentiation, even without external electrical stimulation. Moreover, different bioactive molecules such as growth factors (FGF-2, IGF-1, etc.) or inorganic "therapeutic" ions (zinc, magnesium, etc.) are alternatives to enhance cell differentiation into different tissues.

    Therefore, the combination of conductive biomaterials and bioactive molecules to enhance muscle regeneration represents an exciting opportunity in muscle tissue engineering. This thesis project aims to develop and characterize novel electroactive biomaterials with different compositions, structures and properties and evaluate their potential to treat musculoskeletal regeneration, as well as its combination with inorganic ions looking forward to discovering new conductive biomaterial-therapeutic ions synergies in terms of muscle differentiation.