Superchaotropicity, a New Mechanism for the Intracellular Delivery of Bioactive Molecules Using Boron Clusters

• Autores: Giulia Salluce
• Directores de la Tesis: Javier Montenegro García (dir. tes.), Irene Lostalé Seijo (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2023
• Idioma: inglés
• Tribunal Calificador de la Tesis: Francisco Corzana López (presid.), María Tomás Gamasa (secret.), Gilles Gasser (voc.)
• Programa de doctorado: Programa de Doctorado en Ciencia y Tecnología Química por la Universidad de Santiago de Compostela y la Universidad de Vigo
• Materias:
  • Química
    • Química inorgánica
      • Compuestos de boro
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • The internalization of bioactive molecules is a key issue in various research fields. Hydrophilic compounds do not penetrate cells unless they are assisted by a class of molecules called carriers. To date, most artificial carriers have been designed based on amphiphilicity. However, these molecules have some limitations. In this thesis, we present a new class of direct membrane transporters that leaves behind the amphiphilic paradigm. These carriers are globular boron clusters: anionic, inorganic, and water-soluble, able to interact both with the membranes and the cargo. With this project, we want to demonstrate that superchaotropic carriers could be used for a completely new mechanism of translocation across the membrane.