Resumen de Secretory markers of dense-core vesicles in Alzheimer´s disease
The regulated secretroy pathway in a hallmark of professional secretory cells as neurons and encodrine cells. Significant peptidergic neurotransmitters as hormones, neurtrophins and growth factors are targeted to dense-core vesicles (DCVs) and released after stimulation. DCV secretroy markers include garnins, caerboxuypeptidaseds and proportein convertases and contitute DCV molecular machinery, In adition to their important intracellolar roles in sorting, trafficking and processint of peptidergic cargos, extgracellular neurotrophic functions have been proposed for certain DCV markers Of note, variations in some members of the granin family such as chromogranin A (CgA) have been described in the brain and cerebrosipinal fluid (CSF) of Alzheimer´s disease (AD) patients. However, other abundant DCV secretory proteins as the granin Sglll, the enzyme converatse CPE and the proprotein convertases PC1 and PC2, have been poorly studied in AD.
