Quorum sensing and oral biofilm: an alternative for the prevention and treatment of oral diseases

• Autores: Ana Parga Martínez
• Directores de la Tesis: Ana Otero (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2023
• Idioma: inglés
• Tribunal Calificador de la Tesis: Miguel María Cámara García (presid.), Sabela Balboa Méndez (secret.), Rubén León Berríos (voc.)
• Programa de doctorado: Programa de Doctorado en Avances en Biología Microbiana y Parasitaria por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias de la vida
    • Microbiología
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • The present thesis investigates the potential of inhibiting bacterial cell-cell communication, quorum sensing (QS), to modulate oral biofilm formation. The thesis evaluates the effect of a quorum quenching (QQ) enzyme that degrades N-acylhomoserine lactones, the QS signals of gram-negative bacteria, on in vitro polymicrobial oral biofilms. The potential interactions between AHLs and a gram-positive representative, Enterococcus faecalis, were also investigated. The results presented here support the translation of QQ strategies to in vivo trials for the modulation of oral biofilms. In addition, a more intricate role of AHLs on oral biofilm formation and interactions with gram-positive bacteria is proposed.