Therapeutic alternatives for the treatment of ocular inflammatory diseases

• Autores: Xurxo García Otero
• Directores de la Tesis: Francisco Javier Otero Espinar (dir. tes.), Anxo Fernández Ferreiro (dir. tes.), Pablo Aguiar Fernández (dir. tes.), José Blanco Méndez (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2022
• Idioma: inglés
• Número de páginas: 287
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems.