Electro and magnetically active polymer-based hybrid microenvironments for muscle tissue engineering
- Autores: Bruno Filipe da Costa Hermenegildo
- Directores de la Tesis: Leyre Pérez Álvarez (dir. tes.), Senén Lanceros Méndez (dir. tes.)
- Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2022
- Idioma: inglés
- Tribunal Calificador de la Tesis: José Carlos Rodríguez Cabello (presid.), Leire Ruiz Rubio (secret.), Silvia Barbosa Fernández (voc.), Pedro Ribeiro (voc.), José Luis Vilas Vilela (voc.)
- Programa de doctorado: Programa de Doctorado en Ciencia y Tecnología de Materiales por la Universidad del País Vasco/Euskal Herriko Unibertsitatea
- Materias:
- Enlaces
- Tesis en acceso abierto en: ADDI
- Resumen
An arrangement of cells in an adequate support has been shown to be the best way to mimic the natural microenvironment of tissues. Polymer structures have become the most suitable materials to create this support structure due to their tailorable properties and multifunctional properties. In fact, electro- and magnetoactive polymer based materials are increasingly being used to develop active microenvironments for cell stimulation.This work focuses on the study and development of polymer-based hybrid materials, functionalized with ionic liquids or magnetoelectric particles, to be used as scaffolds for the treatment of tissue injuries, defects and degenerative diseases, using concepts and technologies from the fields of tissue engineering, nanotechnology, physics, chemistry and biology.Various polymer materials and morphologies were processed and characterized, with and without either ionic liquids or magnetoelectric particles. They were tested in in-vitro conditions, to evaluate any possible toxic effects, and when relevant, their mechanical properties and degradability were assessed as well.
