Determining the role of the zinc-finger protein ZMYM2 in pluripotency

• Autores: Yara Souto Becerra
• Directores de la Tesis: Miguel Angel Fidalgo Pérez (dir. tes.), Celia María Pombo Ramos (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2022
• Idioma: inglés
• Tribunal Calificador de la Tesis: Franceso Faiola (presid.), Diana Guallar Artal (secret.), Sonia María Mulero-Navarro (voc.)
• Programa de doctorado: Programa de Doctorado en Medicina Molecular por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias de la vida
    • Biología celular
      • Cultivo celular
    • Genética
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Mutations of the zinc finger MYM-type containing 2 (ZMYM2) protein alter cellular and tissue homeostasis, but its functional roles in pluripotency are largely unexplored. Here, I show that ZMYM2 is a key component of the core regulatory network that governs pluripotency. My data reveal that ZMYM2 is a roadblock to efficient somatic cell reprogramming and is required to fine-tune the self-renewal of ESCs and the early differentiation process. Mechanistically, I found that ZMYM2 and LSD1 associate for the transcriptional control of pluripotency and differentiation genes. This study therefore establishes a novel transcriptional regulatory mode dedicated to reprogramming and pluripotency, and open new avenues for exploring the involvement of ZMYM2- LSD1 partnership in development and disease.