New Catalytic Routes to Benzofused Seven-Membered Azaheterocycles

• Autores: Álvaro Velasco Rubio
• Directores de la Tesis: Carlos Saa Rodríguez (dir. tes.), Jesus Angel Varela Carrete (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2021
• Idioma: inglés
• Tribunal Calificador de la Tesis: José Luis Mascareñas Cid (presid.), Mercedes Amat Tusón (secret.), Igor Larrosa Guerrero (voc.)
• Programa de doctorado: Programa de Doctorado en Ciencia y Tecnología Química por la Universidad de Santiago de Compostela y la Universidad de Vigo
• Materias:
  • Química
    • Química inorgánica
      • Compuestos organometálicos
    • Química orgánica
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Benzazepines, benzodiazepines and benzoxazepines compose a privileged family of natural products and pharmaceuticals. Their remarkable biological activity made them useful drugs to treat a large variety of issues. The design of new catalytic sustainable routes to these nuclei still remains as a main challenge to the organic chemistry. In this thesis the synthesis of these three nuclei upon generation of a key metalp- allyl intermediate through Csp2-H activation, allylic C-H activation, and Rh-hydride catalysis have been successfully accomplished.