Desenvolvimento de novas tecnologias baseadas em materiais biocidas

• Autores: Marcelo de Assis
• Directores de la Tesis: Juan Andrés (dir. tes.), Elson Longo da Silva (dir. tes.), Jefferson Bettini (codir. tes.), Eva M. Guillamón Torres (codir. tes.)
• Lectura: En la Universitat Jaume I ( España ) en 2021
• Idioma: español
• Tribunal Calificador de la Tesis: Regina Célia Galvao Frem (presid.), Yara Galvao Gobato (secret.), Mauricio Roberto Bomio Delmonte (voc.), Tatiana Martelli Mazzo (voc.)
• Materias:
  • Física
    • Física del estado sólido
      • Interfases
      • Conductores metálicos
  • Ciencias médicas
    • Medicina interna
      • Enfermedades infecciosas
  • Ciencias tecnológicas
    • Tecnología electrónica
      • Dispositivos semiconductores
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • The worldwide outbreak of the coronavirus pandemic (COVID-19) and other emerging microbial infections have attracted particular interest in the design and development of new biocidal agents with a broad spectrum of activity. Since then, efficient strategies need to be implemented for the rapid diagnosis, prevention, control and treatment of the SARS-CoV-2 virus, its variants, and other opportunistic pathogens. In the current scenario of SARS-CoV-2 infections, the technological challenge lies in the development of economically viable biocidal systems, reusable and capable of inactivating opportunistic pathogens, thus reducing the risk of infection and transmission. In this sense, Ag-based materials used in small quantities can become attractive for the development of new biocidal technologies. α-Ag2WO4, which already shows biocidal activity, when modified by electrons or femtosecond laser increases its biocidal activity increased up to 32 times, against resistant bacteria (methicillin-resistant Staphylococcus aureus) and fungi (Candida albicans) due to the generated metal-semiconductor interface (Ag/α-Ag2WO4). In addition, this modification makes this interface selective for combating bladder cancer cells (MB49), when compared to versus healthy cells (BALB/3T3), using model mouse cells model. Ag/SiO2 immobilized on ethylene vinyl acetate (EVA) was another studied interface studied was Ag/SiO2 immobilized on ethylene vinyl acetate (EVA) which showed 99.99% inhibition of bacteria (Staphylococcus aureus and Escherichia coli) and fungi (Candida albicans), besides to eliminating in just 2 minutes over 99% of SARS-CoV-2 virus replicates. In this way, safe biocidal technologies can be obtained using silver-based metal-semiconductor interfaces, which can be applied to the design of personal protective equipment (PPE), packaging, fabrics, hygienic implements such as implants and prostheses, and other devices economically feasible to combat the increase in pandemics and fatal risks associated with various pathogens.