The effective communication of brain network dynamics under different states
- Autores: Josephine Cruzat
- Directores de la Tesis: Gustavo Deco (dir. tes.), Rodrigo Rocamora Zúñiga (codir. tes.)
- Lectura: En la Universitat Pompeu Fabra ( España ) en 2020
- Idioma: español
- Tribunal Calificador de la Tesis: Morten L. Kringelbach (presid.), Ernest Montbrió (secret.), Joana Cabral (voc.)
- Programa de doctorado: Programa de Doctorado en Biomedicina por la Universidad Pompeu Fabra
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- Resumen
Cognitive processing requires to flexibly combine information from functionally specialized neural processes that are widely distributed throughout the brain. Neuroimaging studies have consistently reported that functional network configurations are governed by two fundamental principles of brain organization: functional segregation and integration. Yet, the mechanisms underlying the dynamic network reorganization are not well understood. In this work, we present evidence for two mechanisms through which the dynamic system-level integration is modulated. On the one hand, the large- scale brain organization is mediated by transient changes in phase- synchronization, facilitating global information flow between distant cortical areas as proposed by the "Communication Through Coherence" (CTC) theory. And in the other, it is mediated by the ascending neuromodulatory system. Neuromodulators constrain local processes by selectively changing the balance of the excitation and inhibition of individual brain regions.
