Epigenetic modulation of the immune system in early childhood: from infectious diseases to vaccines

• Autores: Sara Pischedda
• Directores de la Tesis: Antonio Salas Ellacuriaga (dir. tes.), Federico Martinón Torres (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2021
• Idioma: inglés
• Tribunal Calificador de la Tesis: Laura Sánchez Piñón (presid.), U. Toscanini (secret.), Francesca Brisighelli (voc.)
• Materias:
  • Ciencias de la vida
    • Biología humana
      • Genética humana
    • Inmunología
      • Vacunas
    • Biología vegetal (botánica)
    • Virología
      • Virus respiratorios
  • Ciencias médicas
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Epigenetic mechanisms regulate gene expression and transcription in a dynamic way. Many functional differences observed in the immune system of neonates and adults seem to be associated with epigenetic modifications of genes that control inflammation and immune response. One of the most studied epigenetic mechanisms is DNA methylation, considered as the major epigenetic factor influencing gene activities. Using the Infinium Illumina Methylation BeadChip platform it was possible to provide insights on the role of epigenetic mechanisms, especially DNA methylation alterations, in the different respiratory sequelae observed after RSV infection and in the variable immune response observed after PCV13 in early childhood.