The regulatory roles of micrornas in bone remodeling and osteoporosis
- Autores: Laura de Ugarte Corbalán
- Directores de la Tesis: Adolfo Díez Pérez (dir. tes.), Natàlia Garcia Giralt (codir. tes.)
- Lectura: En la Universitat Pompeu Fabra ( España ) en 2016
- Idioma: español
- Tribunal Calificador de la Tesis: Francesc Ventura Pujol (presid.), Daniel Prieto Alhambra (secret.), Jordi Carbonell Abelló (voc.)
- Programa de doctorado: Programa de Doctorado en Biomedicina por la Universidad Pompeu Fabra
- Materias:
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- Resumen
In bone field, microRNAs (miRNAs) have been described as key factors regulating bone formation, remodeling, and homeostasis. The identification of miRNAs involved in skeletal function will be essential to the development of miRNA-based therapeutic strategies for bone disorders. As with other regulatory molecules, miRNAs are frequently subject to change during the development of human diseases. In this regard, we identified a subset of miRNAs with altered expression in osteoporotic bone and demonstrate the functional involvement of some of those miRNAs in the regulation of bone formation and the pathways regulating the progression of osteoporosis. We also have depicted an overview of miRNAs in the human bone tissue and in primary bone cells. Furthermore, we have identified genetic variants in human osteoblast-related miRNAs associated with bone mineral density and this association was functionally demonstrated in bone and osteoblast samples. This work has provided evidences of the marked complexity behind this regulatory system and opens novel prospect for research and therapy.
