Preparation and characterization of antigen loaded chitosan nanoparticles for immunization

• Autores: Maruthi Prasanna
• Directores de la Tesis: Noemi Stefania Csaba (dir. tes.), Cyrille Grandjean (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2020
• Idioma: inglés
• Tribunal Calificador de la Tesis: Antonio José Almeida (presid.), Maria Victoria Lozano Lopez (secret.), María José Alonso Fernández (voc.), Rosana Simón Vázquez (voc.), Bernard Offmann (voc.)
• Programa de doctorado: Programa de Doctorado Erasmus Mundus en Nanomedicina e Innovación Farmacéutica por la Universidad de Santiago de Compostela; The University of Nottingham(Reino Unido); Université Catholique de Louvain(Bélgica); Université D'Angers(Francia); Université de Liège(Bélgica) y Université de Nantes(Francia)
• Materias:
  • Ciencias de la vida
    • Inmunología
      • Vacunas
  • Ciencias médicas
    • Farmacología
      • Preparación de medicamentos
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • The currently available pneumococcal vaccines are not effective in complete prevention of pneumococcal infections. To develop a better vaccine, firstly, we produced a glycoconjugate antigen based on common pneumococcal vaccine. Based on the positive immune responses generated by the glycoconjugate antigen in the mice, we further envisage that their combination with the nanotechnologies would generate a vaccine with enhanced potential. In this line, we utilized chitosan nanoparticles to encapsulate the glycoconjugate. Finally, the developed nanovaccines generated an enhanced immune response against both the protein and polysaccharide components when compared to the naked glycoconjugate.