Nanotechnology for the modulation of the immune response in HIV and cancer

• Autores: Tamara Gómez Dacoba
• Directores de la Tesis: María José Alonso Fernández (dir. tes.), José Crecente Campo (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2020
• Idioma: inglés
• Tribunal Calificador de la Tesis: Mariano Esteban Rodríguez (presid.), Noemi Stefania Csaba (secret.), Derek O'Hagan (voc.)
• Programa de doctorado: Programa de Doctorado en Investigación y Desarrollo de Medicamentos por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias de la vida
    • Inmunología
      • Vacunas
  • Ciencias médicas
    • Farmacología
      • Preparación de medicamentos
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Nanotechnologies with the ability to modulate the immune system can be exploited to develop new advanced therapies. The first part of this thesis describes a potential HIV vaccine candidate consisting of nanoparticles loaded with up to three peptide antigens. Based on the good responses in terms of protection against viral infection in macaques, the quality-by-design and scaling-up production of this vaccine candidate was performed. Finally, in the context of cancer, a potential immunotherapy with the capacity to polarize tumor-associated macrophages towards anti-tumoral phenotypes was developed.