The effect of chromatin compaction modification on the efficacy of anticancer medicaments

• Autores: Sara González Carro
• Directores de la Tesis: Fernando Domínguez Puente (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2020
• Idioma: inglés
• Tribunal Calificador de la Tesis: Francesc Mitjans Prat (presid.), Clara María Ruiz Ponte (secret.), Miguel Taron Roca (voc.)
• Programa de doctorado: Programa de Doctorado en Nanomedicina por la Universidad de A Coruña; la Universidad de Santiago de Compostela y la Universidad de Vigo
• Materias:
  • Química
    • Bioquímica
      • Quimioterapia
  • Ciencias de la vida
    • Genética
  • Ciencias médicas
    • Patología
      • Oncología
    • Farmacodinámica
      • Quimioterapia
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Genomic DNA of eukaryotic cells is packaged in a nuclear complex called chromatin that serves as a regulatory platform by limiting nuclear machinery access to DNA. This work goal was to explore whether chromatin has a similar effect on drug-DNA binding. Previous results obtained in our group show that Ag3-AQCs reduce chromatin compaction and improve the efficacy of drugs like oxaliplatin, carboplatin, CDDP and DOX. In this work we explored whether this mechanism is specific, or if a reduction in chromatin compaction can improve DNA accessibility to drugs and, therefore, chemotherapeutic medicaments efficacy. Changing chromatin compaction increased CDDP and DOX binding to DNA in genetic and pharmacological models.