Peptide and protein-polymer: sudy of their applications in nanoengineering and bioengineering
- Autores: Daniel Ernesto López Pérez
- Directores de la Tesis: Carlos Alemán Llansó (dir. tes.)
- Lectura: En la Universitat Politècnica de Catalunya (UPC) ( España ) en 2014
- Idioma: español
- Tribunal Calificador de la Tesis: Sebastián Muñoz Guerra (presid.), Jordi Llorca Piqué (secret.), Xavier Barril Alonso (voc.), Jordi Casanovas Salas (voc.), Jordi Poater Teixidor (voc.)
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- Resumen
The principal focus of this Thesis is the development and design of promising hybrid nanocomposites based on conducting polymers with the main objective of achieving applications in the field of nanoengineering and bioengineering. The main lines of research can be summarized as follows:
1) Study the assembly of Fmoc-tetrapeptides based on the bioactive RGD sequence. More specifically, this Thesis has been focused on the Fmoc-RGDS adhesion motif and its homologue Fmoc-GRDS, wich contains the same residues but in a scrambled sequence. 2) Examine the electron transfer mechanism of the alpha-helical peptide, Cys-Ala-Lys-(Glu-Ala-Ala-Ala-Lys)2-Ala, on gold as function of the molecular stretching understanding the role played by intermolecular 3) Construct a bioactive platform with capacitive properties to be used as a biocondenser by combining the electrochemical advantages of PEDOT and both the bactericidal activity and biocompatibility of lysozyme.
4) Fabricate electro-compatible bioactive platforms by combining two relatively incompatible materials: a soluble conducting polymer and collagen, the major structural protein in animals.
Some research findings provided in this Thesis have been published or accepted for publication in scientific journals:
1.Self-assembly of Fmoc-tetrapeptides based on the RGDS cell adhesion motif . V. Castelleto, C.M. Moulton, G. Cheng, I.W. Hamley, M.R. Hicks, A. Rodger, D.E. López-Pérez, G. Revilla-López and C. Alemán, Soft Matter, 2011, 24, 11405.
2. Intermolecular interactions in electron transfer through stretched helical peptides. D.E. López-Pérez, G. Revilla-López D. Jacquemin, D. Zanuy and C. Alemán, Phys. Chem. Chem. Phys., 2012,14, 10332.
3. Molecular insights into aggregates made of amphiphilic Fmoc-tetrapeptides. D.E. López-Pérez, G. Revilla-López D., I.W. Hamley and C. Alemán, Soft Matter, 2013, 9, 11021 4.Capacitive Composites Made of Conducting polymer and Lysozyme: Toward the biocondenser. D.E. López-Pérez, D. Aradilla, L. J. del Valle and C. Alemán, J.Phys. Chem., 2013, 117, 6607. * .Fabrication of Collagen-Polythiophene Composites as Bioactive Platforms with Cellular Electrocompatibility D.E. López-Pérez, C. Illera and C. Alemán .
*sent and pending acceptance
