Optimization of thrombolytic therapy in brain pathology

• Autores: Clara Correa Paz
• Directores de la Tesis: Francisco Campos Pérez (dir. tes.), Tomas Sobrino Moreiras (dir. tes.), José Antonio Castillo Sánchez (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2019
• Idioma: inglés
• Tribunal Calificador de la Tesis: Ignacio Lizasoain Hernández (presid.), Pablo Hervella Lorenzo (secret.), Marina Rubio Gómez (voc.)
• Programa de doctorado: Programa de Doctorado en Medicina Molecular por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias médicas
    • Patología
      • Neuropatología
      • Trombosis
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Ischemic stroke is the leading cause of disability in the developed countries. The only approved drug treatment is the recombinant tissue plasminogen activator (rtPA). However, its use is limited due to the short half-life side effects. In this study we have developed rtPA-loaded nanocapsules combined with ultrasound application, which we used as trigger to induce rtPA from our nanocapsules. These nanocapsules were also able to extend the half-life of rtPA after in vivo administration and reach the ischemic region. Overall, we have developed promising nanocapsules for the triggered release of rtPA in the brain with potential application in ischemic stroke.