Poly(phenylacetylene)s with peptide substituents: structure and applications
- Autores: Esteban Suárez Picado
- Directores de la Tesis: Emilio Quiñoá Cabana (dir. tes.), Félix Manuel Freire Iribarne (codir. tes.)
- Lectura: En la Universidade de Santiago de Compostela ( España ) en 2019
- Idioma: español
- Tribunal Calificador de la Tesis: Jaime Rodríguez (presid.), María Magdalena Cid Fernández (secret.), Jeanne Crassous (voc.)
- Programa de doctorado: Programa de Doctorado en Ciencia y Tecnología Química por la Universidad de Santiago de Compostela y la Universidad de Vigo
- Materias:
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- Resumen
This Doctoral Thesis is focused on the preparation of brand new peptide-based poly(phenylacetylene)s (PPAs) with targeted functions. Polymeric systems based on biomimetic structures allowed developing stimuli-responsive materials in both water and organic media with potential applications as sensors where controlled conformational changes at pendants lead a preferred helical sense in highly dynamic PPAs studied. Moreover, a novel macromolecular gear was designed, bearing a helical pendant moiety that is able to promote a specific helical sense and scaffold, depending on solvent changes. Finally, a new family of water-soluble helical polymers were generated to evaluate their sensorial abilities when facing different external stimuli such as metal ions, solvent, chiral or achiral molecules, or even pH.
