Enzyme-functionalized hybrid mesoporous nanodevices for sensing, controlled release and molecular communication

• Autores: Antoni Llopis Lorente
• Directores de la Tesis: Félix Sancenón Galarza (dir. tes.), Ramón Martínez Máñez (dir. tes.)
• Lectura: En la Universitat Politècnica de València ( España ) en 2019
• Idioma: español
• Tribunal Calificador de la Tesis: Enrique Victor García-España Monsonís (presid.), María José Bañuls Polo (secret.), Belén Albela (voc.)
• Programa de doctorado: Programa de Doctorado en Química por la Universitat de València (Estudi General) y la Universitat Politècnica de València
• Materias:
  • Química
    • Química analítica
    • Química inorgánica
    • Química orgánica
      • Química de organosilícicos
• Enlaces
  • Tesis en acceso abierto en: RiuNet
• Resumen

  • This PhD thesis entitled "Enzyme-functionalized hybrid mesoporous nanodevices for sensing, controlled release and molecular communication" is focused on the design, synthesis, characterization and evaluation of several hybrid organic-inorganic nanodevices using Janus gold-mesoporous silica nanoparticles as scaffolds, equipped with enzymes, fluorescent species and molecular gates.

    In conclusion, these studies show that the incorporation of enzymes on nanoparticles allows to introduce recognition capabilities with high specificity and to design advanced nanodevices for different purposes. The combination of hybrid nanoparticles with organic groups such as molecular gates, enzymatic effectors and chromo-fluorogenic species or drugs can be very versatile; and we hope that the obtained results inspire the development of new smart materials with application in different areas such as nanomedice and sensing.