Catalytic ruthenium vinyl carbenes. Properties, reactivity and applications in tandem reactions

• Autores: Damián Padín Santos
• Directores de la Tesis: Carlos Saa Rodríguez (dir. tes.), Jesus Angel Varela Carrete (codir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2019
• Idioma: español
• Tribunal Calificador de la Tesis: Antonio M. Echavarren Pablos (presid.), Fernando José López García (secret.), Janine Cossy (voc.)
• Programa de doctorado: Programa de Doctorado en Ciencia y Tecnología Química por la Universidad de Santiago de Compostela y la Universidad de Vigo
• Materias:
  • Química
    • Química orgánica
      • Compuestos heterocíclicos
      • Compuestos organometálicos
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• Resumen

  • The properties of metal carbenes have attracted the interest of the scientific community for decades. Their role in catalytic transformations such as olefin and enyne metathesis, cyclopropanation or C-H bond functionalization has significantly broadened the arsenal of organic synthetic operations. Importantly, these chemical species have also proved to be very versatile in the development of tandem reactions that allow to generate high molecular complexity from simple starting materials. In this thesis, we report our findings on the development of several tandem reactions based on the in situ generation of ruthenium vinyl carbenes through carbene/alkyne metathesis. Special attention has been paid to understand how electronic and geometric factors in ruthenium vinyl carbenes affect to the chemo- and stereoselectivity of the reactions discussed.