Endogenous systems involved in the development of pancreatic cancer: role of the obestatin/GPR39 system

• Autores: Lara Sofía Estévez Pérez
• Directores de la Tesis: Rosalía Gallego Gómez (dir. tes.), Yolanda Pazos Randulfe (codir. tes.), J. Enrique Domínguez Muñoz (codir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2019
• Idioma: inglés
• Tribunal Calificador de la Tesis: Francisco X Real (presid.), M. Clara Alvarez Villamarin (secret.), María Dolores Mayán Santos (voc.)
• Programa de doctorado: Programa de Doctorado en Endocrinología por la Universidad de Santiago de Compostela y la Universidad de Vigo
• Materias:
  • Ciencias de la vida
    • Fisiología humana
    • Biología molecular
  • Ciencias médicas
    • Medicina interna
      • Endocrinología
    • Patología
      • Oncología
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Pancreatic cancer is one of the most aggressive neoplasms due to its rapid spread and late diagnosis. The objective of this thesis is to elucidate the obestatin/GPR39 potential as a therapeutic target in chronic pancreatitis and pancreatic cancer. The expression of GPR39 found in normal pancreas indicates a possible regulatory and regenerative role for the obestatin/GPR39 system in the human pancreas. Likewise, the expression found in premalignant lesions could involve this system in the pathogenesis and progression to pancreatic adenocarcinoma. In addition, this system favours proliferative, invasive and tumoral settlement processes in immortalized cancer cell lines. These facts prompted us to postulate the use of GPR39 as a marker of tumoral progression and its applicability to antagonize the fundamental mechanisms associated with the development of pancreatic cancer.