Functional and structural characterization of peptides derived from hiv-1 gp41 membrane proximal and transmembrane domains. Implications for anti-hiv inhibitor and inmunogen development

• Autores: Beatriz Apellaniz Unzalu
• Directores de la Tesis: Jose Luis Nieva Escandón (dir. tes.)
• Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2012
• Idioma: español
• Tribunal Calificador de la Tesis: Jesús Pérez Gil (presid.), Francesc Xabier Contreras Gómez (secret.), Jamie K. Scott (voc.), Gorka Basañez Asua (voc.), Enrique Pérez Payá (voc.)
• Materias:
  • Química
    • Química analítica
      • Análisis bioquímico
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• Resumen

  • 1- Relevant in vitro assays for MPER membrane activity should include:- MPER peptide redefined to bear the hydrophobic-at-interface region plus the Nterminalresidues of the TMD.- A lipid bilayer whose composition includes concentrations of cholesterol as highas those present in the viral envelope.2- Preliminary results support that in vitro assays for MPER activity, optimizedaccording to those parameters, are useful tools for new HIV-1 inhibitor and immunogendevelopment.