Intramolecular carbolithiation and palladium-catalyzed c-c bond forming reactions in the construction of medium sized rings. Selective synthesis of fused indolizine, pyrroloazepine and pyrroloazocine

• Autores: Estíbaliz Coya Díaz de Sarralde
• Directores de la Tesis: María Nuria Sotomayor Anduiza (dir. tes.), Maria Esther Lete Exposito (dir. tes.)
• Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2013
• Idioma: español
• Tribunal Calificador de la Tesis: José Luis García Ruano (presid.), Antonia Mielgo Vicente (secret.), María Elena González Nuñez (voc.), José Luis Vicario Hernando (voc.), Alessandro Mordini (voc.)
• Materias:
  • Química
    • Química orgánica
      • Compuestos heterocíclicos
      • Compuestos organometálicos
      • Estereoquímica y análisis conformacional
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• Resumen

  • The research work described in this thesis has focused on the develop`ment of new methods for he syntehesis of heterocycles using organolithium intermediates and palladium-catalyzed coupling reactions for the formation of carbon-carbon bonds.the intramolecular carbolithiation reactionor arylithiums has been extended to the construction of medium sized rings, and has also been applied to heteroaryllilthiums. Besides, the competion between Mizoreoki-Heck and direct arylation reaction in the construction of medium sized rings on both aromatic and heteroaromatic systems has been studied. In this context, the asymmetric version of mizoroki-heck reactions, as well as cascade processes have also been studied. Thus. efficient procedures for the obtention of fused indlizine, pyrroloazepine and pyrroloazocine systems have been developed.