Supervised and unsupervised investigation of the temporal dynamics of normal and pathological behaviour in the mouse and rat
- Autores: Maria Isabel Carreño Muñoz
- Directores de la Tesis: Abdelmalik Moujahid Moujahid (dir. tes.)
- Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2017
- Idioma: inglés
- Tribunal Calificador de la Tesis: Yann Herault (presid.), F. Sánchez Santed (secret.), Aline DESMEDT (voc.)
- Materias:
- Enlaces
- Tesis en acceso abierto en: ADDI
- Resumen
Modern neuroscience highlights the need for designing sophisticated behavioral readout of internal cognitive states. From a thorough analysis of classical behavioral test, my results supports the hypothesis that sensory ypersensitivity might be the cause of other behavioural deficits, and confirm the potassium channel BKCa as a potentially relevant molecular target for the development of drug medication against Fragile X Syndrome/Autism Spectrum Disorders. I have also used an innovative device, based on pressure sensors that can non-invasively detect the slightest animal movement with unprecedented sensitivity and time resolution, during spontaneous behaviour. Analysing this signal with sophisticated computational tools, I could demonstrate the outstanding potential of this methodology for behavioural phenotyping in general, and more specifically for the investigation of pain, fear or locomotion in normal mice and models of neurodevelopmental and neurodegenerative disorders.
