Periodontal disease and cerebral atherosclerotic disease: translational study

• Autores: Yago Leira Feijoo
• Directores de la Tesis: José Antonio Castillo Sánchez (dir. tes.), Juan Blanco Carrión (codir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2018
• Idioma: inglés
• Tribunal Calificador de la Tesis: Mariano Sanz Alonso (presid.), Susana Arias Rivas (secret.), German O. Gallucci (voc.)
• Programa de doctorado: Programa de Doctorado en Ciencias Odontológicas por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias médicas
    • Medicina interna
      • Neurología
    • Patología
      • Arterioesclerosis
      • Endotoxinas
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Although an association has been established between periodontal disease (PD) and large vessel ischemic stroke, little is known about the relationship between PD and lacunar infarct (LI), a subtype of cerebral small vessel disease that is responsible for almost 25% of the ischemic stroke cases. Our aim was, therefore, to investigate whether PD is linked with LI and if so, to study potential mechanisms underlying this association. In the present study we found that PD was positively associated with LI and, when present, emerged as one of the main contributors to an enhanced systemic inflammatory state promoting endothelial dysfunction with elevated levels of IL-6, PTX3, sTWEAK, and Aβ1-40 in LI patients. Moreover, moderate to severe active PD was an independent predictor of poor functional outcome in LI patients. These findings were corroborated in a preclinical in vivo study in the rodent model, in which experimental PD induced with lipopolysaccharide from Porphyromonas gingivalis was associated with a mild systemic inflammatory response with disruption of the vascular endothelial function.