Resumen de The sea lamprey GABAB receptor: Changes after spinal cord injury and its role in axonal regeneration
Spinal cord injury (SCI) causes irreversible loss of function. In contrast to mammals, lampreys show an amazing capacity for spontaneous recovery after a complete SCI. In this study, we analysed the changes in the expression of both gabab subunits after a complete SCI. Our results showed that plastic changes in this system probably contribute to the recovery of function after SCI in lampreys. Pharmacological and genetic manipulations revealed that GABA acting through GABAB receptors promotes axonal regeneration of descending neurons after a complete SCI in lampreys.
