Cold thermoreceptors of the cornea: functional characteristics

• Autores: Andrés Parra Martín
• Directores de la Tesis: Carlos Belmonte Martínez (dir. tes.), Rodolfo Madrid Montecinos (codir. tes.)
• Lectura: En la Universidad Miguel Hernández de Elche ( España ) en 2012
• Idioma: español
• Tribunal Calificador de la Tesis: Peter Mcnaughton (presid.), Antonio Vicente Ferrer Montiel (secret.), Ana Gomis García (voc.), Karel Talavera (voc.), Ana Mª de los Angeles Sánchez García (voc.)
• Materias:
  • Ciencias de la vida
    • Fisiología humana
      • Neurofisiología
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• Resumen

  • Basal tearing is crucial to maintaining ocular surface wetness. Corneal cold thermoreceptors sense small oscillations in ambient temperature and change their discharge accordingly. Deletion of the cold-transducing ion channel Transient receptor potential cation channel subfamily M member 8 (TRPM8) in mice abrogates cold responsiveness and reduces basal tearing without affecting nociceptor-mediated irritative tearing. Warming of the cornea in humans also decreases tearing rate. These findings indicate that TRPM8-dependent impulse activity in corneal cold receptors contributes to regulating basal tear flow.