Resumen de Factor de necrosis tumoral alpha como marcador de inflamación en fumadores sanos
- español
Los fumadores tienen valores más elevados que los no fumadores de la citosina proinflamatoria TNF-α en suero. No existen diferencias en los valores de TNF-α en condesado de aire exhalado (CAE) entre fumadores y no fumadores. El sexo no demuestra ser un factor determinante en los niveles de TNF-α en ninguno de los medios estudiados. A mayor edad de los sujetos, se pueden encontrar mayores niveles de TNF-α en suero. No existe influencia de la edad sobre los valores de TNF-α en CAE. Un mayor índice de masa corporal (IMC) influye en mayores niveles de TNF-α plasmáticos. No existe relación entre el IMC y los valores de TNF-α en CAE. El tiempo de duración del hábito tabáquico influye más sobre la inflamación sistémico que el consumo diario. Los niveles de TNF-α en CAE no se modifican por ninguno de los parámetros de consumo de tabaco. La función pulmonar (FVC y débilmente FEV1) guarda relación con los valores plasmáticos de TNF-α. Los parámetros de función pulmonar no influyen en los valores de TNF-α en CAE.
- English
The aims of this study were to demonstrate an inflammatory status of healthy smokers in comparison to a group of healthy non smokers by measuring the levels of a proinflammatory citokyne: TNF-α. We also wanted to know whether there was influence of gender, age and weight on TNF-α levels; and to determine the association between smoking, pulmonary function and TNF-α. We made a prospective study of smokers and non-smokers without any known disease. Respiratory function tests, samples of exhaled breath condensate (EBC) and blood were performed before smoking cessation. Statistical analysis were made with SPSS 11.0. We studied 51 patients, 60,8% smokers (n = 31), 56,9% female (n = 29), mean age 39,88 +/- 7,61 years old, and mean body mass index (BMI) 25,33 +/- 5,74 kg/m2. There were no significant differences between the two groups, except for BMI that was higher in smokers (26,50 vs 23,53 kg/m2, p = 0,044). Smokers had significant higher levels of TNF-α in plasma (6,54 pg/ml vs 5,88 pg/ml, p = 0,043), but there were no differences in TNF-α in EBC (4,03 pg/ml vs 4,05 pg/ml, p = 0,89). Age and BMI has an influence on the levels of serum TNF-α, but not in EBC values. Of the parameters of smoking studied, only the age when smoking first began had an influence on TNF-α plasma values, but not in EBC TNF-α levels. In terms of lung function, we just found a correlation between FVC and FEV1 (porcentual values) with serum TNF-α (not in EBC). In conclusion, we can say that healthy smokers showed higher levels of TNF-α in serum but not in EBC when compared to non smokers. There was an influence of body mass index on serum TNF-α levels. The time when smoking started is the main data of tobacco consumption that influenced the levels of TNF-α in plasma. There was a correlation between lung function and serum TNF-α.
