Sex differences in ochratoxin A nephrotoxicity: A molecular approach to the mechanism of action

• Autores: Laura Pastor Castro
• Directores de la Tesis: Adela López de Cerain Salsamendi (dir. tes.), Ariane Vettorazzi Armental (codir. tes.)
• Lectura: En la Universidad de Navarra ( España ) en 2017
• Idioma: inglés
• Número de páginas: 244
• Tribunal Calificador de la Tesis: María del Pilar Lostao Crespo (presid.), Paul Cordero (secret.), Fermín Ignacio Milagro Yoldi (voc.), Eduardo de la Peña Torres (voc.), Francisco Javier Campión Zabalza (voc.)
• Programa de doctorado: Programa de Doctorado en Alimentación, Fisiología y Salud por la Universidad de Navarra
• Materias:
  • Ciencias médicas
    • Toxicología
• Enlaces
  • Tesis en acceso abierto en: Dadun
• Resumen

  • This work is included in the line of research carried out in Toxicology which studies the mycotoxin ochratoxin A (OTA) from the point of view of its mechanism of action. OTA causes various toxic effects, such as nephrotoxicity, hepatotoxicity, immunosuppression, neurotoxicity and teratogenicity. However, the main issue concerning OTA effect is its carcinogenic potential in kidney, the target organ. The aim of this research project was to explore the impact of sex on OTA-induced gene expression response in order to determine the key events that might be involved in the early events of the carcinogenic process.