The role of the cationic and helper lipids on niosomes for gene delivery applications: transfection of retina and brain as a main goal.

• Autores: Edilberto Ojeda Hernandez
• Directores de la Tesis: José Luis Pedraz Muñoz (dir. tes.), Gustavo Puras Ochoa (codir. tes.)
• Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2016
• Idioma: inglés
• Tribunal Calificador de la Tesis: Alfonso Jesús Ladislao Domínguez-Gil Hurlé (presid.), Laura Saenz del Burgo Martínez (secret.), Eduardo Ruiz Hernandez (voc.), Maria de los Angeles Martinez de Pancorbo Gomez (voc.), Ramón Eritja Casadellà (voc.)
• Materias:
  • Ciencias médicas
    • Farmacología
      • Análisis de medicamentos
      • Evaluación de medicamentos
      • Preparación de medicamentos
• Enlaces
  • Tesis en acceso abierto en: ADDI
• Resumen

  • Currently, gene delivery has become a tangible option for the treatment of several diseases. However, there are few available options in the market, where viral vectors are the preferred option due to their high transduction efficiency. Despite the advantages that viral vectors offer, there are still many concerns about their safety. To overcome this issue, non-viral vectors have rouse interesting expectations, specifically on particles based on cationic lipids, where niosomes are a promising approach due to recent findings. Unfortunately, more research is needed bejore niosomes, as gene delivery vectors, can emulate transfection efficiencies obtained with viral vectors and be launched into the market. In the present study, we have prepared and characterized in vitro niosome formulations based on different cationic lipids for their in vivo application in retina and brain.