FLRT proteins act as guidance cues for migrating cortical interneurons

• Autores: Catherine Fleitas Pérez
• Directores de la Tesis: Joaquím Egea Navarro (dir. tes.), Carme Espinet i Mestre (dir. tes.)
• Lectura: En la Universitat de Lleida ( España ) en 2015
• Idioma: inglés
• Tribunal Calificador de la Tesis: Judit Herrero Danés (presid.), Esther Pozas Pulido (secret.), Josep Maria Canals Coll (voc.)
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • The establishment of functional neuronal connectivity starts during development and depends on neuronal migration and the correct positioning of newborn neurons which integrate into specific layers of the cortex. The fibronectin and leucine-rich family of transmembrane proteins (FLRT) have evolved as new regulators of several aspects during nervous system development, including neuronal migration. This work is focused on the study of in vivo FLRTs involvement in the tangential migration of interneurons. For this, we have analyzed nervous system specific knockout animals for FLRT2 and FLRT3, single mutants as well as the double mutants The simultaneous suppression of FLRT2 and FLRT3, resulted in the appearance of several defects related to interneuron migration. Finally, was addressed the intracellular mechanisms involved in FLRT function and was assessed the relationship between FLRT3 and the Rho GTPase Rnd3. The results suggest a possible functional interaction between FLRTs and Rnds in the central nervous system.