Synthesis of antimicrobial peptides derived from BP100 and BPC194

• Autores: Imma Güell
• Directores de la Tesis: Marta Planas Grabuleda (dir. tes.), Lidia Feliu Soley (dir. tes.)
• Lectura: En la Universitat de Girona ( España ) en 2012
• Idioma: inglés
• Tribunal Calificador de la Tesis: Alessandro Tossi (presid.), Judit Tulla Puche (secret.), Gilles Subra (voc.), Juan Carlos Fernandez Collado (voc.), Abdallah Hamze (voc.)
• Programa de doctorado: CIENCIAS EXPERIMENTALES Y DE LA SALUD
• Materias:
  • Química
    • Bioquímica
      • Péptidos
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • In the present PhD thesis we studied the solid-phase peptide synthesis of antimicrobial peptides derived from the lead peptides BP100 and BPC194. First, peptides derived from BP100 containing D-amino acids at different positions of the sequences were prepared. Moreover, peptidotriazoles derived from BP100 were also synthesized containing the triazole ring at the side-chain of different amino acids. Then, we proceeded to perform studies for the synthesis of multivalent peptides derived from BPC194. To achieve this objective, the synthesis of cyclic peptides containig a triazole ring at amino acids side-chain with different elongations was carried out. Finally, we prepared various carbopeptides containing 2 and 4 units of BP100 and/or its derivatives. The evaluation of the biological activity allowed the identification of active sequences against the economically important phytopathogenic bacteria and fungi and not toxic against eukaryotic cells.