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This monograph presents five state-of-the-art articles analysing challenges and trends through paradigm shifts in environment, competitiveness, social cohesion, transportation and global governance. The analysis is enriched with the views and experiences of the different cities that are part of the network. This approach renders a global perspective of local issues. In every thematic area, the topics chosen are trends that are significantly changing the way cities and metropolitan areas address their challenges. Therefore, they emerge as paradigm shifts, that is, new approaches to addressing existing problems, or new conceptualisations of global problems that challenge existing local solutions.