Multi-omics insights into the marine pathogen tenacibaculum maritimum: decoding virulence for vaccine design

• Autores: María del Pilar Escribano Rodríguez
• Directores de la Tesis: Beatriz Magariños Ferro (dir. tes.), Manuel Luis Lemos Ramos (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2025
• Idioma: inglés
• Tribunal Calificador de la Tesis: Jesús Lamas Fernández (presid.), Patricia Pereiro González (secret.), David Pérez Pascual (voc.)
• Programa de doctorado: Programa de Doctorado en Avances en Biología Microbiana y Parasitaria por la Universidad de Santiago de Compostela
• Materias:
  • Ciencias de la vida
    • Inmunología
      • Vacunas
  • Ciencias agrarias
    • Fitopatología
      • Bacterias
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Tenacibaculum maritimum is a Gram-negative marine bacterium and the etiological agent of tenacibaculosis, a disease of major concern for worldwide aquaculture. Despite the increasing relevance of this pathogen, a comprehensive understanding of its virulence strategies and environmental adaptations has remained elusive. This thesis provides an integrative omics-based characterization of key virulence factors in T. maritimum. It underscores the role of OMVs as virulence and vaccine platforms, identifies novel siderophore structures, and maps the transcriptional landscape underlying host adaptation. These findings provide a foundation for the development of more effective preventive strategies in aquaculture and contribute to our broader understanding of host-pathogen interactions in marine ecosystems.