Diferential diagnosis of primary mesenchymal neoplasms of the breast
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Mine Ozsen [1] ; Seyit Ali Volkan Polatkan [1] ; Ulviye Yalcınkaya [1] ; Sahsine Tolunay [1] ; Mustafa Sehsuvar Gokgoz [1]
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[1] Uludağ University
Uludağ University
Turquía
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 1, 2025, págs. 223-232
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Objective While the majority of breast neoplasms originate from epithelial cells, a rare part of them originate from mesenchymal breast tissue. This study aims to present the histomorphological and clinicoradiological features of our series of primary mesenchymal breast tumors and to discuss the features of these tumors in light of the literature.
Materials and methods Cases diagnosed as primary mesenchymal breast tumor in breast resection materials evaluated in our center between 2010 and 2023 were included.
Results Of the 26 tumors included, 57.7% were diagnosed as benign and 42.3% as malignant mesenchymal tumor. Cases diagnosed as benign mesenchymal tumor were hemangioma, lipoma, extra-abdominal fbromatosis, leiomyoma, angiofbroma, lipomatosis, benign fbrous histiocytoma and granular cell tumor. Histopathological study results were compatible with angiosarcoma in 5 (45.4%), undiferentiated sarcoma in 3 (27.3%), myxofbrosarcoma in 2 (18.2%) cases and rhabdomyosarcoma in 1 (9.1%) case.
Conclusion Primary breast sarcomas are rarely seen compared to benign mesenchymal tumors and constitute less than 0.1% of all malignant breast tumors. When histomorphological fndings suggestive of a mesenchymal tumor are observed in breast specimens, sufcient sampling should be performed to exclude a possible phyllodes tumor, and clinicoradiological fndings should be examined to exclude the possibility of a metastasis.
