Treatment patterns and humanistic burden of malignant pleural mesothelioma in Spain
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Susana Cedres [2] ; Julio Calvete [1] ; Gavin Taylor Stokes [3] ; Néstor Álvarez Ayerza [4] ; David Vilanova Larena [4] ; Melinda Daumont [5]
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[1] Hospital Universitario Puerta del Mar
Hospital Universitario Puerta del Mar
Cádiz, España
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[2] Hospital Universitari de La Vall d’Hebron, Barcelona, Spain
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[3] Adelphi Real World, Adelphi Mill, Grimshaw Lane, Bollington, Macclesfeld, Cheshire, UK
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[4] Bristol Myers Squibb, Madrid, Spain
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[5] Bristol Myers Squibb, Braine L’Alleud, Belgium
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 1, 2025, págs. 213-222
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Purpose Malignant pleural mesothelioma (MPM) is an aggressive cancer with long latency and poor prognosis. The realworld treatment patterns and humanistic burden of MPM in an international cohort of patients were recently published. Spanish data are currently lacking and are reported here.
Methods/Patients Data were collected from three sources: physician-abstracted demographic, clinical and treatment characteristics of patients with MPM; patient-completed questionnaires on treatment satisfaction, symptoms, caregiver use, and impact of the disease; and caregiver-completed questionnaire reporting their activity and its impact on their daily life.
Results The 241 patients in Spain were primarily elderly (median age: 67 years), male, retired/unemployed/on long-term sick leave, and diagnosed at stage IV with unresectable disease. Exposure to asbestos was detected (54%, 101/188). Firstline treatment (1L) consisted primarily of doublet chemotherapy (86%, 207/241). Of 102 patients who completed 1L at data abstraction, 67 were receiving maintenance therapy, most commonly singlet chemotherapy with pemetrexed. Best supportive care was given to 29 patients, primarily after 1L (86.2%, 25/29). Symptom burden was high and health-related quality of life was poor and declined with progression: mean (SD) EQ-5D score and EQ-5D visual analogue scale score were 0.615 (0.285) and 60.8 (17.1) in 1L and 0.497 (0.370) and 56.1 (19.5) in second line. Overall, 67% of patients (162/241) required daily assistance from their caregiver, who reported an impact on their psychological well-being.
Conclusions Patients with MPM in Spain were overall treated according to treatment guidelines at the time. Nevertheless, a considerable burden of disease was reported by patients and caregivers.
