Predictive capacity for local disease control of neogenin‑1 (NEO1) transcriptional expression in patients with head and neck squamous cell carcinoma

Xavier León Vintró; Cristina Valero Mayor; Gemma Fuster Orellana; Paloma Bragado Domingo; Mercedes Camacho; Francisco Javier Avilés Jurado

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Predictive capacity for local disease control of neogenin‑1 (NEO1) transcriptional expression in patients with head and neck squamous cell carcinoma

Xavier León ^[1] ; Cristina Valero ^[1] ; Gemma Fuster ^[2] ; Paloma Bragado ^[3] ; Mercedes Camacho ^[4] ; Francesc Xavier Avilés Jurado ^[2]
1. [1] Hospital de la Santa Creu i Sant Pau
  
  Hospital de la Santa Creu i Sant Pau
  
  Barcelona, España
2. [2] Universitat de Barcelona
  
  Universitat de Barcelona
  
  Barcelona, España
3. [3] Universidad Complutense de Madrid
  
  Universidad Complutense de Madrid
  
  Madrid, España
4. [4] Genomics of Complex Diseases, Research Institute Hospital Sant Pau, IIB Sant Pau, Barcelona, Spain
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Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 1, 2025, págs. 160-165
Idioma: inglés
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Resumen
- Purpose To analyze the predictive capacity for local disease control of the transcriptional expression of neogenin-1 (NEO1) gene in patients with head and neck squamous cell carcinoma (HNSCC).
  
  Methods/patients A retrospective study was performed on tumor biopsies from 107 patients with HNSCC treated surgically. The transcriptional expression of NEO1 was determined by RT-PCR. NEO1 transcriptional expression value was categorized according to local disease control by recursive partitioning analysis.
  
  Results Lower NEO1 transcriptional expression was associated with worse local control after surgical treatment. Patients with lower NEO1 expression (n=25, 23.4%) had a 5-year local recurrence-free survival of 61.8% (95% CI: 42.1–81.5%), while patients with higher NEO1 expression (n=82, 76.6%) had a 5-year local recurrence-free survival of 85.6% (95% CI: 77.6–93.6%), (P=0.003). According to the result of multivariable analysis, patients with lower NEO1 expression had a 2.7-fold increased risk of local tumor recurrence (95% CI: 1.0–7.0, P=0.043) compared to patients with higher NEO1 expression.
  
  Conclusions HNSCC patients with a lower transcriptional expression of NEO1 have a signifcantly higher risk of local recurrence after surgical treatment.