Treatment of Osteoporosis in Chronic Kidney Disease Population

• Smith, Pinar Jaclyn ^[1]
  1. [1] Rush University Medical Center

     Rush University Medical Center

     City of Chicago, Estados Unidos

     
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 53, Nº. 4, 2024 (Ejemplar dedicado a: Updates on Osteoporosis Diagnosis and Therapy), págs. 525-529
• Idioma: inglés
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• Resumen

  • The definition of chronic kidney disease (CKD) is a 3-month duration of a glomerular filtration rate (GFR) less than 60 mL/min, albuminuria of greater than 30 mg per 1 g creatinine, or abnormal renal imaging.1 Diabetes and hypertension are the leading causes of chronic kidney disease, and less common causes include vascular disease and glomerulonephritis. Chronic kidney disease causes hyperphosphatemia, hypocalcemia due to decreased 1-alpha-hydroxylase activity to activate vitamin D2 that lead to a secondary hyperparathyroidism (appropriately elevated parathyroid hormone in response to a derangement)1 A patient’s risk of a fragility fracture doubles when his/her GFR falls